"ʻO kēia mau mea i loaʻa i ka hapa nui e pōmaikaʻi mai ka ʻenehana ʻenehana, ka hoʻokele maʻamau a me ka hana ʻōmaʻomaʻo."Ua ʻōlelo ʻo Zhang Ge, "Mahalo i ka hoʻoikaika ʻole ʻana o Deebio no ke kiʻekiʻe kiʻekiʻe, ua loaʻa i nā huahana bio-enzyme API nā mea maikaʻi e like me ka hana kiʻekiʻe, ka maʻemaʻe kiʻekiʻe a me ke kūpaʻa kiʻekiʻe a no laila ʻike nui ʻia e nā hoa."

Hana maikaʻi loa

ʻO nā bio-enzymes nā protein me nā hana catalytic, he ʻokoʻa ia mai nā protein ʻē aʻe i loaʻa iā lākou kahi kikowaena ikaika.Loaʻa ka API o nā bio-enzymes ma o ka hoʻokaʻawale ʻana, ka unuhi a me ka hoʻomaʻemaʻe ʻana mai nā meaola.

"ʻO Bio-enzyme API kahi ʻoihana me ka hoʻopukapuka nui, haʻahaʻa haʻahaʻa a me ka pilikia ʻenehana kiʻekiʻe.Heʻuʻuku ka pālākiō ʻoihana.A he liʻiliʻi nā hui e hana nei. "Wahi a Zhang Ge, ʻo ka pilikia ʻenehana kiʻekiʻe ma muli o ka hana o nā enzymes e paʻakikī i ka hana hoʻomaʻemaʻe.No ka laʻana, inā ʻaʻole i hoʻomalu maikaʻi ʻia ke kaʻina hana, ʻaʻohe hana o ka huahana, a laila nalowale kona waiwai lapaʻau.

ʻO Bio-enzyme API kekahi o nā mea maka o ka bio-pharmaceuticals.Me ka haʻahaʻa haʻahaʻa a me nā hopena ʻaoʻao, ʻo ka bio-pharmaceuticals i manaʻo nui ʻia no ka mālama ʻana i kekahi mau maʻi a maʻalahi ke komo ʻia e ke kino kanaka.Loaʻa iā ia nā hopena therapeutic kūʻokoʻa no ka maʻi diabetes, nā maʻi cardiovascular, nā ʻōpū a me nā maʻi viral.

"ʻO koʻu manaʻo koʻikoʻi ʻo ia ka lōʻihi o kaʻu hana ʻana i ka mea a nā poʻe ʻē aʻe, hana wau i ka mea maikaʻi loa."Manaʻo ʻo Zhang Ge ʻo ke kumu i hoʻokumu ʻia ai ʻo ia i ka ʻoihana bio-enzyme no nā makahiki he 20 ʻoi aku kona aloha i nā enzymes.I ka makahiki 1990, ma hope o kona puka ʻana mai ke Kulanui ʻo Sichuan (Ke Kulanui o ʻEpekema a me ʻenehana ʻo Chengdu mua) ma ka biochemistry, ua hana ʻo Zhang Ge ma ke ʻano he ʻenehana a ma hope ka luna hoʻokolohua ma Deyang Biochemical Pharmaceutical Factory.ʻElima mau makahiki ma hope mai, ma muli o ka hoʻoponopono hou ʻana o ka hale hana, ua lawe ʻo ia i ka ʻoihana.

"I kēlā manawa, ua kokoke e hoʻololi ʻia ka hale hana biochemical i ʻoihana lāʻau lapaʻau.Ua hele au i ka hale hana e nānā a ʻike i kekahi poʻe ʻōpio e hoʻoponopono hou ana i kahi hale hana liʻiliʻi kahiko.Ua uhi ʻia ko lākou mau maka i ka wai a me ka lepo.Aia ma waena o lākou ʻo Zhang Ge.Ua hoʻomanaʻo ʻo Zhong Guangde, ka Hope Luna Hoʻokele mua o ka Sichuan Provincial Medical Administration Bureau, me ka manaʻo, "ʻO Zhang Ge ke kanaka ʻōpio e hana nei i nā mea pono i koʻu mau maka."

I Kekemapa 1994, ua hoʻokumu ʻo Zhang Ge iā Sichuan Deyang Biochemical Products Co., Ltd. I ka wā i hoʻokumu ʻia ai, aneane lilo ia i banekorupa.

"I nā makahiki 1990 mua, ʻaʻole ikaika ka ʻike maikaʻi o ka ʻoihana Bio-enzyme o Kina, a ua kaupalena ʻia ko mākou ʻike i nā enzyme i ka ʻike ua lawa ka hana enzyme maikaʻi."Wahi a Zhang Ge, i Malaki 1995, ua loaʻa i ka Deyang Biochemical Products Co., Ltd. kāna kauoha mua no ka kallidinogenase crude no ka lawe ʻana aku i ka mākeke Iapana.Eia naʻe, ua hōʻole ʻia nā huahana ma muli o ka ʻokoʻa o kekahi mau milligrams i ka momona momona."Inā noi ka ʻaoʻao i ka uku, e lilo ka ʻoihana i ka panakalupa, a ʻo ka nui o ka uku he hōkū no ka hui i kēlā manawa.ʻO ka mea pōmaikaʻi, ma o ka hoʻonohonoho ʻana, ʻaʻole i noi mai ka ʻaoʻao ʻē aʻe iā mākou e hōʻemi akā e hāʻawi hou mākou i nā huahana, "wahi a Zhang Ge.

Ua aʻo kēia ʻike iā Zhang Ge, ka mea e hoʻomaka ana i kahi ʻoihana, kahi haʻawina koʻikoʻi a hoʻomaopopo iā ia ʻo ka maikaʻi o ka huahana ke koko ola o kahi hui.I nā makahiki 27 o ka hoʻomohala ʻana, ua mālama mau ka ʻoihana i nā kūlana koʻikoʻi.Ma muli o nā makahiki o ka noiʻi maʻamau, ua hoʻomaikaʻi mau ʻo Deebio i kāna ʻenehana, no laila e hana ana i ka pale ʻana i ka hana enzyme holoʻokoʻa, ka hoʻoulu ʻole ʻana a me ka ʻenehana hoʻomaʻemaʻe pololei e hōʻoia i ka hana kiʻekiʻe, ka maʻemaʻe kiʻekiʻe a me ke kūpaʻa kiʻekiʻe o nā huahana Bio-enzyme API.

ʻAʻohe hoʻoikaika ʻana e hoʻokomo i ka hana hou

"Hōʻike ʻia ka ʻoihana bio-enzyme API e nā liʻiliʻi a me ka hoʻololi ʻana.Me ka ʻole o ka ʻenehana, ʻaʻole hiki i hoʻokahi a ʻelua paha huahana ke kākoʻo i kahi ʻoihana e hoʻomohala.Hoʻokahi wale nō huahana ʻo Deebio mai kona hoʻokumu ʻana.Akā i kēia lā, ʻoi aku ka nui o nā API bio-enzyme, ʻaʻole hiki ke hoʻokaʻawale ʻia mai kā mākou hoʻomau mau ʻana i ka ʻenehana.wahi a Zhang Ge.

ʻO Trypsin-Chymotrypsin kahi enzyme proteolytic i hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia mai ka porcine pancreas.ʻO ia kekahi o nā huahana nui a Deebio.Ua pōmaikaʻi ka R&D o kēia huahana mai ka hui ʻoihana-university-noiʻi.I ka makahiki 1963, ua hoʻohana ʻo Qi Zhengwu, he mea noiʻi ma ka Shanghai Institute of Physiology and Biochemistry o ka Chinese Academy of Sciences, i ka recrystallization e unuhi i kahi aniani hui o chymotrypsin a me trypsin mai ka porcine pancreas, i kapa ʻia ʻo trypsin-chymotrypsin.ʻAʻole i hana ʻia kēia enzyme ma mua o 30 mau makahiki.Ua ʻike ʻo Zhang Ge i ka manawa kūpono i loko."I ka makahiki 1997, ua hui pū mākou me ka hui noiʻi o ka mea hoʻonaʻauao Qi Zhengwu e ʻike i ka hoʻomohala ʻana o trypsin-chymotrypsin a loaʻa i nā pono waiwai a me ka pilikanaka.I kona manawa maikaʻi loa, ʻoi aku ma mua o 20 tons i ka makahiki o kēia huahana i lawe ʻia i India.Wahi a Zhang Ge, ua hōʻike ʻo Qi Zhengwu i ka mea hoʻonaʻauao "Maikaʻi loa, ua hana ʻia kaʻu huahana e nā kūlanakauhale a me nā ʻoihana kauhale.'

Ma hope o ka hoʻāʻo ʻana i ka ʻono o ka ʻenehana hou, ua hoʻonui hou ʻo Deebio i kāna hoʻopukapuka ʻana i ka ʻenehana, a ua hoʻomohala i ka launa pū ʻana o ka ʻoihana-university-noiʻi me Tsinghua University, Chinese Academy of Science, Sichuan University, China Pharmaceutical University a me nā kula ʻē aʻe o ka hoʻonaʻauao kiʻekiʻe a me nā keʻena noiʻi. , e hana pū i nā laboratories, e hoʻomaikaʻi mau i ka noiʻi ʻepekema o ka hui a me ka hiki ke hana hou a kūkulu i kahi hui hana a me R&D me ka hiki ke hoʻololi ʻenehana kiʻekiʻe i loaʻa iā 15 mau ʻenehana patented.

I mea e hoʻomaikaʻi hou aku ai i ka maikaʻi o ka huahana, ma 2003, ua hui pū ʻo Deebio me kahi hoa Kelemania me ka ʻenehana ʻoi aku ka holomua a me ka hiki ke hoʻokele e hoʻokumu i kahi hui hui i kapa ʻia ʻo Deyang Sinozyme Pharmaceutical Co., Ltd. "I kēlā makahiki, ua hoʻopukapuka mākou ma mua o 20 miliona yuan e kūkulu i kahi mea kanu hou, me nā lako hana i kūkulu ʻia me nā mea kiʻekiʻe o ka honua.I ka manawa like, hiki ke kūkulu ʻia kahi hale hana ma Kina no 5 miliona yuan.ʻO ke kumukūʻai o ke kūkulu ʻana iā Sinozyme ua like ia me 4 mau hale hana.Wahi a Zhang Ge, ua kipa ka hoa Kelemania i ka hui e alakaʻi i nā lā he ʻumi i kēlā me kēia mahina.Me ka hoʻokomo ʻana i nā ʻano hoʻokele ʻōnaehana kūlana kiʻekiʻe, ua hoʻokiʻekiʻe ʻia ka mana hoʻokele ʻōnaehana maikaʻi o Sinozyme i ka pae honua kiʻekiʻe.

I ka makahiki 2005, ua lilo ʻo Sinozyme i hui pancreatin Kina mua i loaʻa ka palapala EU-GMP;ma 2011, ua hoʻokumu ʻia ʻo Sichuan Deebio Pharmaceutical Co., Ltd.;ma 2012, loaʻa iā Deebio ka palapala hōʻoia CN-GMP;i Ianuali 2021, ua hoʻokumu ʻia ʻo Deebio (Chengdu) Bio-technology Co., Ltd. no ka R&D, ka hana ʻana a me ka hoʻohana ʻana i nā lāʻau lapaʻau kiʻekiʻe a me nā hoʻomākaukau enzyme biotechnology.

"Manaʻo wau e makemake nā ʻoihana e hoʻopukapuka i ka ʻenehana hana hana.Ua kūkulu ʻo Deebio i hale hana hou i kēlā me kēia 7 a 8 mau makahiki.I kēia mau makahiki, ua hoʻokomo ʻia ka hapa nui o nā loaʻa kālā i ke kūkulu ʻana i ka ʻoihana, ka hoʻololi ʻana i nā lako hana a me ka hoʻokomo ʻana i nā talena.Loaʻa i nā mea kuleana a me nā luna hoʻokele liʻiliʻi nā mahele. "ʻO Zhang Ge, he ʻenekinia mua, hoʻomaopopo piha i ke koʻikoʻi o ka hoʻopukapuka ʻenehana.Ua mālama ʻo ia i ka wikiwiki o ka hana hou, a ua helu i kahi moʻo o nā mea e hana ai: ʻO ka hale hana GMP hou o Deebio i kūkulu ʻia e like me nā kūlana FDA i hoʻomaka i ka makahiki i hala a manaʻo ʻia e hoʻopau ʻia i ka hopena o Mei a komo i ka hana hoʻokolokolo;ʻO Deebio (Chengdu) Bio-technology Co., Ltd., aia ma Wenjiang, Chengdu, hoʻomaka ʻia ke kūkulu ʻana ma ʻApelila 26 a manaʻo ʻia e hoʻohana ʻia i ʻOkakopa.

“ʻO Green Production kaʻu e haʻaheo loa ai”

ʻO ka haumia o ka API ka mea e hopohopo mau ai i ke kaiāulu, a ua lilo ka palekana o ke kaiapuni i wahi koʻikoʻi e hoʻoholo ai i ke ola o nā ʻoihana.ʻO ka pili ʻana i ka hana ʻōmaʻomaʻo ka mea e haʻaheo loa ai ʻo Zhang Ge.

"I ka wā o ka hoʻomohala mua ʻana o ka ʻoihana, ʻaʻole mākou i nānā nui i nā pilikia kaiapuni.Akā, i ka wā i hoʻopuka ai ka ʻāina i nā pono palekana o ka nohona, ua hoʻomaka mākou e ʻike i kona koʻikoʻi.Wahi a Zhang Ge, i nā makahiki he ʻumi i hala iho nei, ua nānā nui ʻo Deebio iā ia, e hoʻoikaika ana e hoʻokō i ka hoʻomohala hoʻomau.

He hanana ia i hoʻololi ai."Ma kahi hālāwai i nā makahiki he nui i hala aku nei, ua hoʻolālā nā luna o kā mākou hui i kahi huahana e pono ai i kekahi mau reagents kemika.ʻAʻole hiki ke hoʻohaʻahaʻa ʻia kekahi o nā mea hoʻohui kemika, a inā e hoʻokuʻu ʻia ka wai ʻino i loko o ka muliwai, hiki ke hōʻeha i nā pēpē.ʻAʻohe oʻu kānalua e ʻōlelo ʻole i kēia huahana. "Ma ke kamaʻilio ʻana no ka mea i hana ʻia, ua ʻoluʻolu loa ʻo Zhang Ge, "Aia koʻu kūlanakauhale ma ka ʻaoʻao o ka muliwai ʻo Tuojiang, ʻoi aku ma mua o 200 mau kilomita mai Guanghan, Sichuan.A kahe ka muliwai e pili ana i kā mākou hale hana i ka muliwai Tuojiang.ʻO ka hoʻokuʻu ʻia ʻana o ka wai ʻōpala he hewa i nā hanauna e hiki mai ana.No laila, ʻaʻole au e hana pēlā.

Mai ia manawa, ua ʻōlelo ʻo Deebio ʻoiai ʻo ke kaʻina hana e pili ana i nā mea ʻawaʻawa a weliweli a i ʻole nā ​​​​mea kōkua i hiki ʻole ke hana ʻia i ka hoʻomohala ʻana i nā huahana hou, ʻaʻole e ʻae ʻia ka hoʻomohala ʻana, a ua koi ʻo ia i ka hoʻopukapuka ʻana i ka mālama ʻana i ke kaiapuni. ma luna o ʻumi makahiki.

I kēia lā, ua kūkulu ʻo Deebio i kahi kikowaena mālama wai ʻino i ka māla me ka nui o ka mālama ʻana i kēlā me kēia lā o 1,000m³, me ka hoʻokuʻu ʻia ʻana o ka wai ʻōpala ma hope o ka hiki ʻana i ka maʻamau.“Ua lawa kēia mana no mākou e hoʻohana ai no ʻumi makahiki.A ua kūkulu kūikawā ʻia kahi māla ma luna o ke kikowaena mālama wai ʻino.Hiki ke hoʻohana ʻia ka wai i mālama ʻia e hānai i nā iʻa a me nā pua wai," wahi a Zhang Ge me ka haʻaheo.

Eia kekahi, hiki ke mālama ʻia ke kinoea ʻōpala e ka pulupulu a me nā ʻano hana ʻē aʻe, a hiki ke hoʻohana ʻia ka biogas e hoʻomaʻamaʻa mua i ka paila ma hope o ka degassing a me ka dehydration, pēlā e mālama ai i ka 800m³ o ke kinoea maoli i kēlā me kēia lā.No nā mea paʻa i hana ʻia, aia kahi hale hana hana paʻa kūikawā.Hoʻololi ʻia ka ʻōpala protein i mea kanu olaola i loko o 4 mau minuke ma o ka mea maloʻo a hoʻouna ʻia i ka mea kanu fertilizer biological.

Ua ʻōlelo ʻo Zhang Ge me ka manaʻo, "I kēia manawa ʻaʻole hoʻopuka ka ʻāina āpau i nā ʻala ʻē aʻe, a ua hoʻomalu ʻia ka wai ʻino a me nā mea haumia ma ke ʻano kūpono.ʻOi aku koʻu haʻaheo i kēia ma mua o ka hana ʻana i nā huahana, ʻo ia ka hoʻokō aʻu i mahalo nui ai. "

E pili ana i ka hoʻomohala ʻana i ka wā e hiki mai ana, piha ʻo Zhang Ge i ka hilinaʻi, "ʻO ka hoʻomohala ʻana o ka ʻoihana e pono ai ka holomua mau.ʻO ka hoʻomohala kiʻekiʻe o ka ʻoihana bio-enzyme API ʻaʻole ia wale nō ka hana ʻana i nā huahana kiʻekiʻe, akā loaʻa pū kekahi ʻenehana ʻoi aku ka maikaʻi, ʻoi aku ka maikaʻi o nā hana, nā koi hoʻokele kiʻekiʻe, a me nā ʻano hana hoʻonaninani.E lawe ʻo Deebio i ke alakaʻi o ka hoʻomohala kiʻekiʻe o ka ʻoihana ma ke ʻano he kuleana, a e lawelawe me ka naʻau holoʻokoʻa i nā kānaka āpau no ko lākou olakino ma ke ala o ka hoʻomohala ʻana.