Pepsin, ka enzyme ikaika i loko o ka wai ʻōpū e hoʻoheheʻe i nā protein e like me nā mea i loko o ka ʻiʻo, nā hua manu, nā ʻanoʻano, a i ʻole nā ​​​​hua waiū.ʻO ka Pepsin ke ʻano hana oʻo o ka zymogen (pūmua inactive) pepsinogen.

PepsinUa ʻike mua ʻia i ka makahiki 1836 e ke kanaka physiologist Kelemania ʻo Theodor Schwann.I ka makahiki 1929, ua hōʻike ʻia kona ʻano crystallization a me ka protein e ka mea biochemist ʻAmelika ʻo John Howard Northrop o ka Rockefeller Institute for Medical Research.(Ua loaʻa iā Northrop kekahi mahele o ka 1946 Nobel Prize for Chemistry no kāna hana i ka hoʻomaʻemaʻe maikaʻi ʻana a me ka crystallizing enzymes.)

Hana a mālama ʻia nā pepsinogen nā ʻeleʻele i loko o ka mucous-membrane o ka ʻōpū.Nā hoʻoikaika mai ka ʻO ke aʻalolo vagus a me nā mea huna hormonal o ka gastrin a me ka secretin e hoʻoulu i ka hoʻokuʻu ʻana o ka pepsinogen i loko o ka ʻōpū, kahi i hui pū ʻia me ka waika hydrochloric a hoʻololi koke i ka pepsin enzyme ikaika.ʻOi aku ka mana hoʻoemi o ka pepsin ma ka ʻakika o ka wai ʻōpū maʻamau (pH 1.5–2.5).I loko o ka ʻōpū ua hoʻokaʻawale ʻia nā ʻakika ʻōpū (pH 7), a ʻaʻole maikaʻi hou ka pepsin.

I loko o ka digestive tract, ʻo ka pepsin wale nō ka hopena o ka hoʻohaʻahaʻa ʻana i nā protein i loko o nā ʻāpana liʻiliʻi i kapa ʻia ʻo peptides, a laila e komo ʻia mai ka ʻōpū i loko o ke kahe koko a i ʻole e wāwahi ʻia e nā enzyme pancreatic.

Hele ka pepsin liʻiliʻi mai ka ʻōpū i loko o ke kahe koko, kahi e wāwahi ai i kekahi o nā ʻāpana nui, a i ʻole ka ʻai ʻole ʻia, nā ʻāpana o ka protein i komo ʻia e ka ʻōpū liʻiliʻi.

ʻO ka hoʻihoʻi hope ʻana o ka pepsin, ka waikawa, a me nā mea ʻē aʻe mai ka ʻōpū i loko o ka esophagus ke kumu no nā kūlana reflux, ʻoi aku ka maʻi reflux gastroesophageal a me ka reflux laryngopharyngeal (a i ʻole ka reflux extraesophageal).Ma ka hope, hele ka pepsin a me ka waikawa a hiki i ka larynx, kahi e hiki ai ke hōʻino i ka mucosa laryngeal a hoʻopuka i nā hōʻailona mai ka haʻahaʻa a me ka maʻi maʻi mau a hiki i ka laryngospasm (ka hoʻopaʻa ʻole ʻana o nā kaula leo) a me ka maʻi maʻi laryngeal.

Deebio's pepsinlawe ʻia mai ka porcine gastric mucosa kiʻekiʻe e kā mākou ʻenehana hoʻoiho kūʻokoʻa.Hoʻohana nui ʻia ia no ka dyspepsia ma muli o ka lawe ʻana i nā meaʻai protein.

Me 30 mau makahiki o ka ʻimi noiʻi ʻepekema a me ka hana ʻenehana, ua hoʻokumu mākou i kahi "DEEBIO 3H Technology" kūikawā, me ka hoʻohana ʻana i ke kaʻina holoʻokoʻa o ka pale enzymatic. ka hana kiʻekiʻe, ka maʻemaʻe kiʻekiʻe a me ke kūpaʻa kiʻekiʻe o nā huahana bio-enzyme.

Welina mai e hoʻokaʻaʻike mai iā mākou, ke kakali nei mākou i ke kamaʻilio ʻana me ʻoe a me ke kali ʻoiaʻiʻo no kāu nīnau